Oocyte-specific linker histone H1foo is an epigenomic modulator that decondenses chromatin and impairs pluripotency
نویسندگان
چکیده
منابع مشابه
Expression of human oocyte-specific linker histone protein and its incorporation into sperm chromatin during fertilization.
OBJECTIVE To investigate the expression of oocyte-specific linker histone protein (hH1FOO) in human ovaries and its incorporation into sperm chromatin after intracytoplasmic sperm injection (ICSI). DESIGN Laboratory study. SETTING University hospital. PATIENT(S) Human ovarian tissues were obtained from patients at oophorectomy. Human oocytes and embryos were obtained from infertile patien...
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Reprogramming of somatic cells to induced pluripotent stem cells involves a dynamic rearrangement of the epigenetic landscape. To characterize this epigenomic roadmap, we have performed MethylC-seq, ChIP-seq (H3K4/K27/K36me3) and RNA-Seq on samples taken at several time points during murine secondary reprogramming as part of Project Grandiose. We find that DNA methylation gain during reprogramm...
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متن کاملH1foo is indispensable for meiotic maturation of the mouse oocyte.
Oocyte-specific linker histone H1foo is localized in the oocyte nucleus, either diffusely or bound to chromatin, during the processes of meiotic maturation and fertilization. This expression pattern suggests that H1foo plays a key role in the control of gene expression and chromatin modification during oogenesis and early embryogenesis. To reveal the function of H1foo, we microinjected antisens...
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ژورنال
عنوان ژورنال: Epigenetics
سال: 2012
ISSN: 1559-2294,1559-2308
DOI: 10.4161/epi.21492